Ehrenstein2000 - Positive-Feedback model for the loss of acetylcholine in Alzheimer's disease

Ehrenstein2000 - Positive-Feedback model for
the loss of acetylcholine in Alzheimer's disease
Curated model derived from

BIOMD0000000553

This model is described in the article:

A positive-feedback model
for the loss of acetylcholine in Alzheimer's disease.

Ehrenstein G, Galdzicki Z, Lange
GD.
Ann. N. Y. Acad. Sci. 2000; 899:
283-291
Abstract:

We describe a two-component positive-feedback system that
could account for the large reduction of acetylcholine that is
characteristic of patients with Alzheimer's disease (AD). One
component is beta-amyloid-induced apoptosis of cholinergic
cells, leading to a decrease in acetylcholine. The other
component is an increase in the concentration of beta-amyloid
in response to a decrease in acetylcholine. We describe each
mechanism with a differential equation, and then solve the two
equations numerically. The solution provides a description of
the time course of the reduction of acetylcholine in AD
patients that is consistent with epidemiological data. This
model may also provide an explanation for the significant, but
lesser, decrease of other neurotransmitters that is
characteristic of AD.

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