Supplementary Table 2.xlsx: Concordance of Acquired Mutations between Metastatic Lesions and Liquid Biopsy in Metastatic Colorectal Cancer

Supplementary
Table 2

RAS
index of primary tumors, normal colonic mucosa, and metastatic lesions using
the RASKET kit

Tb
denotes primary tumor tissue obtained before treatment by biopsy, Ts denotes
primary tumor tissues obtained from surgical resection after initial
chemotherapy, and N denotes normal colonic mucosa obtained from surgical
resection after initial chemotherapy.

K2PC,
K3PC, K117PC, K146PC, N2PC, N3PC, N117PC, and N146PC denote the control of
the amplified wild-type allele of KRAS exon 2, KRAS exon 3, KRAS exon 4
(including codon 117), KRAS exon 4 (including codon 146), NRAS exon 2, NRAS
exon 3, NRAS exon 4 (including codon 117), and NRAS exon 4 (including codon
146), respectively.

*G12C
of the S3 sample was considered a false positive, influenced by the strong
positivity of G12R.

†NRAS
codon 117 and 146 indexes of the 2-RL sample were considered “unrecovered”
because the measured values of the N117PC and N146PC beads were lower than
the cut-off value.