Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation
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https://researchdata.lib.cityu.edu.hk/citation?persistentId=doi:10.82468/VNDRDU
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资源简介：
Comprehensive and unbiased RNA-seq analysis of UMR-106 cells exposed to low vs. high [Na+] revealed several novel genes involved in cellular adaptation to altered tonicity. Additional analysis of cells with Crisp-Cas9 mediated NFAT5 deletion indicated that NFAT5 controls numerous genes associated with FGF23 synthesis, thereby confirming its role in [Na+]-mediated FGF23 regulation. We included 12 datasets in the RNA-Seq data analysis: three biological replicates in each group (control with -NaCl, control with +NaCl, NFAT5KO with -NaCl, and NFAT5KO with +NaCl).
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CityUHK Research Data Repository
创建时间：
2026-03-09
