Promoter-wide profiling of DNA hydroxymethylation in prefrontal cortex of healthy controls

Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings. Although genetic factors with small effect sizes are collectively associated with the pathophysiology of BD, the underlying molecular mechanisms, especially how environmental factors affect the brain genome, remain largely unknown. We revealed neuronal cell-type-specific, pathophysiology-related DNA methylation changes in the prefrontal cortex (PFC) of BD patients, highlighting the importance of the neural epigenome for understanding BD. Promoter-wide profiling of DNA hydroxymethylation in prefrontal cortex of healthy controls. In total 5 samples; 1 reference samples, 2 neuronal nuclei samples, 2 non-neuronal nuclei samples.