Crystal structure of AfNth1-K122A mutant bound to Tg-DNA duplex complex in an intermediate state

Crystal structure of AfNth1-K122A mutant bound to Tg-DNA duplex complex in an intermediate state Descriptor: DNA (5'-D(*AP*CP*GP*CP*GP*AP*(CTG)P*AP*CP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*CP*GP*TP*AP*TP*CP*GP*CP*G)-3'), Endonuclease III, ... Authors: Hitomi, K, Arvai, A.S, Syed, A, Parikh, S, Tainer, J.A. Deposit date: 2025-03-31 Release date: 2026-04-15 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A unified catalytic mechanism in bifunctional DNA glycosylases with an evolutionarily conserved aspartate-lysine dyad. Nat Commun, 2026