Reproducibility archive for pharmacokinetic forgiveness of antiretroviral drugs after a missed dose

This reproducibility archive supports the manuscript “Pharmacokinetic forgiveness of antiretroviral drugs after a missed dose – an exploratory model-based comparative analysis.” It contains locked machine-readable calculation inputs and provenance tables for 22 antiretroviral drug, formulation, or dosing scenarios; Python code for the deterministic common-decay analysis, a 10,000-iteration parameter stress test, and primary structural reconstructions of CAB-LA Q8W, RPV-LA Q8W, and LEN-LA Q26W; fixed random seeds; pinned software-environment specifications; validation tests; expected outputs; generated numerical outputs; and documentation of the targeted evidence-search framework. All inputs were derived from cited aggregate published and regulatory sources. No individual-participant data were used or included. The analyses quantify population-level exposure persistence above selected concentration thresholds. They do not determine whether a missed dose is clinically safe or predict uninterrupted therapeutic effect. The scheduled-time long-acting exposure comparisons are internal implementation-consistency checks and do not constitute external validation.