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Dynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells

ChEBI2013-11-22 更新2026-07-21 收录

细胞分化调控

内胚层发育信号

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-52658 数据链接链接失效反馈

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资源简介：

Dynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells

应用场景：

创建时间：

2013-11-22

细胞分化调控

微流控细胞培养

BackgroundAutocrine & paracrine signaling are widespread both in vivo and in vitro, and are particularly important in embryonic stem cell (ESC) pluripotency and lineage commitment. Although autocrine

NIAID Data Ecosystem50

Expression data from cultured mouse bone-marrow monocytes.

细胞分化调控

肿瘤免疫微环境

Retinoic acid signaling regulates monocyte differentiation into dendritic cells or macrophages. We used microarrays to uncover gene expression changes associated with retinoic acid exposure in mouse m

NIAID Data Ecosystem40

The TH1 cell lineage-determining transcription factor T-bet supresses TH2 gene expression by redistributing GATA3 away from TH2 genes [ChIP-seq series 2]. The TH1 cell lineage-determining transcription factor T-bet supresses TH2 gene expression by redistributing GATA3 away from TH2 genes [ChIP-seq series 2]

细胞分化调控

ChIP-seq分析

Differentiation of progenitor cells into mature cell types is commonly associated with the expression of lineage-determining transcription factors (LD-TFs) specific to that lineage. In CD4+ T cells, T

NIAID Data Ecosystem20

Table_1_Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage.xlsx

细胞分化调控

cDC2亚群分化

Dendritic cell (DC) specification and differentiation are controlled by a circuit of transcription factors, which regulate the expression of DC effector genes as well as the transcription factors them

NIAID Data Ecosystem50

Quaking regulates lineage-specific splicing patterns between early progenitor cells and is required for cardiac cell fate specification

细胞分化调控

发育生物学

Cell type-specific alternative splicing (AS) regulates tissue homeostasis, with several examples of AS promoting stem cell self-renewal or differentiation. However, the lineage-specific patterns of AS

NIAID Data Ecosystem30

Dynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells

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