Activated PCLG1 dissociates from NTRK2

Based on the accepted model of PLCgamma1 (PLCG1) signaling, although this has not been tested in the context of the NTRK2 (TRKB) receptor-mediated activation of PLCG1, phosphorylated, active, PLCG1 dissociates from the receptor tyrosine kinase and catalyzes formation of DAG and IP3 second messengers (Carpener and Ji 1999).

基于PLCgamma1（PLCG1）信号通路被广泛认可的模型，尽管其在NTRK2（TRKB）受体介导的PLCG1激活背景下的应用尚未经过实验验证，但活化的、磷酸化的PLCG1会从受体酪氨酸激酶上解离，催化二酰甘油（DAG）和三磷酸肌醇（IP3）第二信使的形成（参见Carpena和Ji，1999年）。