Cis-regulation between Irf8 enhancers during cDC1 development
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2023-08-02
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Gene expression profile at single cell level of pre-cDCs from the bone marrow, spleen and lung of mice. Gene expression profile at single cell level of pre-cDCs from the bone marrow, spleen and lung of mice
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Batf3 maintains Irf8 autoactivation for commitment of a novel clonogenic progenitor of CD8+DCs
The transcription factors Batf3 and IRF8 are required for development of CD8α+ conventional dendritic cells (cDCs), but the basis for their actions was unclear. Here, we identify two novel Zbtb46+ pro
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The Prolyl Isomerase Pin1 Modulates Development of CD8+ cDC in Mice
BackgroundPin1 has previously been described to regulate cells that participate in both innate and adaptive immunity. Thus far, however, no role for Pin1 has been described in modulating conventional
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Epigenetic and transcriptional regulation of dendritic cell development and anti-tumor function by HDAC1 (CUT&RUN)
DC progenitors adapt their transcriptional program during development generating different subsets. How chromatin modifications modulate these processes is unclear. Here we investigate the impact of h
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