Mif

Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of icosanoid secretion; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cellular senescence; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Nov 2024]

激活细胞因子活性；苯丙酮酸异构酶活性；以及蛋白酶结合活性。参与多种生理过程，包括细胞因子产生的正向调控；二十烷酸分泌的正向调控；以及信号传导的调控。在DNA损伤反应、p53类介导的信号传导、细胞衰老以及细胞增殖的调控等过程中发挥上游或内部作用。位于细胞外空间。在多个结构中表达，包括消化系统；中枢神经系统；泌尿生殖系统；呼吸系统；以及感觉器官。此基因的人类同源基因与过敏性疾病、哮喘、囊性纤维化、多发性肺疾病和肥胖有关。与人类MIF（巨噬细胞迁移抑制因子）同源。[由基因组资源联盟提供，2024年11月]