Expression of PLIN1 regulated by NR1H2 or NR1H3

The perilipin 1 (PLIN1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Liver X receptors (LXRα, NR1H2,3) up-regulate basal human adipocyte lipolysis partially through NR1H2,3 binding to the PLIN1 promoter and down-regulation of PLIN1 expression (Stenson BM et al. 2011). By selective knockdown of either NR1H2 or NR1H3, NR1H3 was found to be the major isoform mediating the lipolysis-related effects of NR1H2,3. The Reactome event of NR1H2,3-regulated expression of PLIN1 is inferred from the analogous event regulated by a synthetic NR1H2,3 agonist GW3965 (Stenson BM et al. 2011).

perilipin 1 (PLIN1) 基因经过转录生成信使RNA (mRNA)，随后mRNA被翻译成蛋白质。肝脏X受体（LXRα、NR1H2、3）通过NR1H2、3与PLIN1启动子的结合以及PLIN1表达的下调，部分上调了人类脂肪细胞的基底脂解作用（Stenson BM 等人，2011年）。通过对NR1H2或NR1H3的特异性敲低，发现NR1H3是NR1H2、3介导脂解相关效应的主要异构体。NR1H2、3调控PLIN1表达的反应途径事件（Reactome）可从由合成NR1H2、3激动剂GW3965调控的类似事件中推断出来（Stenson BM 等人，2011年）。