FGFR3 Kinase Domain with Inhibitor TYRA-300

FGFR3 Kinase Domain with Inhibitor TYRA-300 Descriptor: (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole, Fibroblast growth factor receptor 3, GLYCEROL, ... Authors: Hoffman, I.H, Nelson, K.J, Rideout, M.C, Nix, J.C, Frye, C, Bensen, D.C, Hudkins, R.L. Deposit date: 2024-06-24 Release date: 2024-09-25 Last modified: 2024-10-02 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia. J.Med.Chem., 67, 2024