Change in T2-LV and T1-LV over time in patients with increasing and decreasing VW-MTR (mm³).

aFailed analysis or missing MRI at Week 24. bFor the difference from zero within groups from the Wilcoxon signed–rank test. cAdjusted for multiple comparisons with the Holm-Bonferroni correction. dFor the difference between the first 12 weeks and the second 12 weeks from the Wilcoxon signed–rank test. LV, lesion volume; Max, maximum; Min, minimum; MRI, magnetic resonance imaging; NS, non-significant; SD, standard deviation; VW-MTR, voxel-wise magnetic transfer ratio.