Gold-Catalyzed Intramolecular Indole/Alkyne Cyclization Cascades through a Heterolytic Fragmentation: 1,5-Indole Migration and Allenylation

Gold-catalyzed intramolecular reactions of 3-alkynyl-bearing indoles with diol groups lead to the formation of highly functionalized 3-allenylindoles with high efficiency. The reaction likely proceeds by a new gold-catalyzed cascade cyclization/heterolytic fragmentation/elimination reactions, which results in 1,5-indole migration and C-3 allenylation of indole moiety.

金催化下，3-炔基取代吲哚与二醇基团发生的分子内反应，高效地生成高度功能化的3-丙烯基吲哚。该反应可能通过一种新型的金催化级联环化/异裂解/消除反应进行，从而导致1,5-吲哚迁移和吲哚结构单元的C-3丙烯基化。