Tea polyphenols induce hepatotoxicity by interfering with adult zebrafish lipid metabolism and gut microbiota through the gut-liver axis
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP505641
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资源简介：
High-dose tea polyphenols may promote fatty acid absorption by hepatocytes by up-regulating FABP, CD36 and SRB1 genes, inhibiting fatty acid efflux by down-regulating ABCA1 genes, and inhibiting fatty acid beta oxidation by down-regulating CPT1 and ACAA2 genes, resulting in fat accumulation in hepatocytes, upregulation of inflammatory pathways, and increased expression of pro-inflammatory factors TNF-a and IL1-b.
创建时间：
2024-05-06
