Structure of kRas G12C bound to Inhibitor 13ab

Structure of kRas G12C bound to Inhibitor 13ab Descriptor: 1-((2R,5S)-4-((S)-6-chloro-7-(1,6-dimethyl-1H-indazol-7-yl)-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-2,5-dimethylpiperazin-1-yl)prop-2-en-1-one, CALCIUM ION, GLYCEROL, ... Authors: Shaffer, P.L, Milligan, C, Peters, U. Deposit date: 2026-01-29 Release date: 2026-04-15 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Optimization of Covalent 6-Cyanoquinazoline KRAS G12C Inhibitors for the Treatment of Solid Tumors. J.Med.Chem., 69, 2026