Expression data from myeloid progenitors derived from control and antibiotic-treated wild-type C57BL/6 mice

Myeloid progenitors derived from antibiotic-treated mice have cell-intrinsic functional defects. In this microarray dataset, the transcriptomes of bone marrow myeloid progenitors from antibiotic-treated and control mice are compared. Myeloid progenitors from antibiotic-treated mice have a reduced interferon gene expression signature. These data suggest that tonic interferon signaling is sensed by myeloid progenitors and such signals are reduced in antibiotic-treated mice. A total of 16 samples were analyzed comparing myeloid progenitors (CMPs, GMPs, and cMoPs) from control and antibiotic-treated mice. Differentially expressed genes were identified between myeloid progenitors from antibiotic-treated mice and control mice using a two-way ANOVA statistical test in Partek Genomics Suite software and corrected for multiple testing using the Benjamini-Hochberg procedure to calculate a false discovery rate (FDR) of <0.2.