Robust and scalable differentiation of human pluripotent stem cells into high-quality hepatocyte-like cells (HLC) is achieved by acting on Wnt/b-catenin and TGFb pathways and taking advantage of lates

NIAID Data Ecosystem20

gut microbiota disorder associated with sepsis-associated liver dysfunction (SALD) in patients with intra-abdominal infection

脓毒症肝功能障碍

肠道菌群动态

Fecal samples were collected on day 1,3 and 7 after ICU admission to analyze the changes of gut microbiota by 16S rRNA sequencing in IAI patients with or without SALD.

NIAID Data Ecosystem10

Single cell RNA-sequencing of iPS cells derived multicellular human liver organoids. Single cell RNA-sequencing of iPS cells derived multicellular human liver organoids

单细胞转录组学

肝脏类器官建模

By taking advantage of the foregut generation method, we initially differentiated iPSCs to foregut spheroids through definitive endoderm specification as described. The foregut spheroids were embedded

NIAID Data Ecosystem30

Integrative multi-omics analysis in sepsis-associated liver dysfunction

脓毒症肝功能障碍

多组学整合分析

we conducted integrative multiple levels of omics data including transcriptome, phosphoproteome, proteome and metabolome in different time-course of sepsis-associated liver dysfunction (SALD). This is

NIAID Data Ecosystem10

A human iPSC-derived multilineage liver organoid model containing Kupffer cells to study human sepsis-associated liver dysfunction

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