Crystal structure of RXR alpha LBD bound to a synthetic agonist FN537 and a coactivator fragment

Crystal structure of RXR alpha LBD bound to a synthetic agonist FN537 and a coactivator fragment Descriptor: (6R,6aR,7S,10R,10aS)-6-(3,5-bis(trifluoromethyl)phenyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-3-carboxylic acid, 6S,6aS,7R,10S,10aR)-6-(3,5-bis(trifluoromethyl)phenyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-3-carboxylic acid, Nuclear receptor coactivator 2, ... Authors: Morozov, V, Merk, D, Nawa, F. Deposit date: 2025-04-15 Release date: 2025-08-13 Last modified: 2025-08-27 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Development of an RXR Agonist Scaffold with Pronounced Homodimer Preference. J.Med.Chem., 68, 2025