Mitochondrial nutrient utilization underlying the association between metabolites and insulin resistance in adolescents.

Participants were enrolled in the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) project which was started in 1994 and consists of three sequentially-enrolled birth cohorts from Mexico City Maternity Hospitals (20). A subset of these children, age 8-14 years, were contacted through their primary caregiver to provide urine samples, serum samples, anthropometry and complete an interview-based questionnaire (n=250). Subjects for this analysis have baseline and follow data on anthropometry, metabolic biomarkers and adequate serum volume for metabolomics analyses (n=206).