The crystal structure of PDE6D in complex to inhibitor-7
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The crystal structure of PDE6D in complex to inhibitor-7 Descriptor: 4-[[[4-[(4-chlorophenyl)methyl-cyclopentyl-sulfamoyl]phenyl]sulfonyl-(piperidin-4-ylmethyl)amino]methyl]-2-(methylamino)benzoic acid, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Authors: Fansa, E.K, Martin-Gago, P, waldmann, H, Wittinghofer, A. Deposit date: 2016-12-06 Release date: 2017-02-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angew. Chem. Int. Ed. Engl., 56, 2017
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2016-12-06
