Reduction in mean tone by isoprenaline and forskolin with or without pre-incubation with K_v7 channel modulators (10μM) in human DSM isolated strips.

Mean tone is reported as mean difference ± SEM% in comparison to time-matched vehicle-control at 30 μM forskolin or 3 μM isoprenaline. Positive and negative modulators are denoted by Pos. and Neg., respectively, and AC stands for adenylyl cyclase. Each datapoint is n = 4–9 patients. Statistically significant differences were evaluated by t-test, *P<0.05, ***P<0.001 compared to vehicle control, § compared to isoprenaline or # compared to forskolin. Reduction in mean tone by isoprenaline and forskolin with or without pre-incubation with Kv7 channel modulators (10μM) in human DSM isolated strips.