Gut heart axis in aortic stenosis

科学数据银行2025-10-27 更新2026-04-23 收录

肠道微生物组与主动脉瓣狭窄

生物标志物研究

数据链接：

https://www.scidb.cn/detail?dataSetId=56e5372f3aab444dbc4f58ae36603ad3 数据链接链接失效反馈

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资源简介：

The Human Microbiome Project in Aortic Stenosis investigates the composition and functional role of the intestinal microbiota in patients with degenerative aortic valve disease. Stool samples are collected from individuals with clinically confirmed aortic stenosis as well as from matched control groups, including patients with aortic regurgitation and bacteremia. Using 16S rRNA gene amplicon sequencing (V3–V4 region, Illumina MiSeq), the project aims to characterize taxonomic shifts, identify microbial biomarkers, and explore potential gut–heart interactions contributing to systemic inflammation and valvular calcification. The overarching goal is to define specific microbial signatures linked to inflammatory and metabolic pathways involved in aortic stenosis progression.

提供机构：

Department of Cardiac Surgery, Heart Center Bonn, University Hospital Bonn; Institute of Molecular Medicine and Experimental Immunology, Faculty of Medicine, University Hospital of Bonn; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn; University Hospital Bonn; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn; Department of Medicine-II, Heart Center Bonn, University Hospital Bonn; Core Unit for Bioinformatics Data Analysis, Medical Faculty, University of Bonn; Muntadher Al Zaidi

创建时间：

2025-10-27