Processed Seurat objects from scRNA-seq data of the aging subventricular zone (SVZ) neurogenic niche with partial reprogramming

This repository contains the processed Seurat objects from the publication "Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche" (https://doi.org/10.1038/s43587-024-00594-3). Raw sequencing data is available at the Gene Expression Omnibus (GEO) under accession number GSE224438. Code used to process and analyze the data is available on GitHub (https://github.com/gitlucyxu/SVZreprogramming). These Seurat objects are filtered to high-quality singlets for samples included in the publication. Descriptions and notable metadata: svz_iOSKM_cohort1_toshare.rds - SVZ after whole-body partial reprogramming, cohort 1 Celltype - cell type annotation Treatment - condition untr: old control 2Dox0: old+OSKM hash.ID - mouse ID (biological replicate) svz_iOSKM_cohort2_toshare.rds - SVZ after whole-body partial reprogramming, cohort 2 Celltype - cell type annotation Age_Treatment - condition young_untr: young control old_untr: old control old_2Dox0: old+OSKM hash.ID - mouse ID (biological replicate) svz_ciOSKM_toshare.rds - SVZ after SVZ-targeted partial reprogramming Celltype - cell type annotation Age_Treatment - condition young_untr: young control old_untr: old control old_Dox: old+OSKM(SVZ) MULTI_classification_rescued - mouse ID (biological replicate) Updated 2024/07/01 (v2): replaced a corrupted file.