Project CLEAR

MRSA Absence-Presence Dataset <br> MRSA isolates were collected as part of the CLEAR (Changing Lives by Eradicating Antibiotic Resistance) Trial. The trial was designed to compare the impact of a repeated decolonization protocol plus education on general hygiene and environmental cleaning to education alone on MRSA infection and hospitalization. Study subjects in the trial were recruited from hospitalized patients based on an MRSA positive culture or surveillance swabs. After recruitment, swabs were obtained from different body parts of subjects (nares, skin, throat, and wound) around the time of hospital discharge (ENRL) and at 1,3,6 and 9 months (V1-V4, respectively) following the initial visit, after which the swabs were cultured on chromogenic agar. The application of decolonization protocol lasted only for 6 months, and consequently, we only modeled visits until V3 in this study. We note that some enrolled study subjects, despite a positive culture (clinical or surveillance) during the hospital stay, did not have discharge swabs positive for MRSA at the first time point (ENRL). The data used in this study are collected from people aged over 18 (average age=56, SD=17) for both the education and decolonization groups, with eligibility requirements also including hospitalization within previous 30 days and positive testing for MRSA during the enrollment hospitalization or within the 30 days before or afterwards. Exclusion criteria included hospice care and allergy to the decolonization products. Over the course of the trial, 98 of 1063 participants (9.2%) in the education group and in 67 of 1058 (6.3%) in the decolonization group developed MRSA infections, and 84.8% of the MRSA infections resulted in hospitalization. More details about recruitment and eligibility, follow up, sample collection, and data preprocessing can be found in the reference https://www.nejm.org/doi/10.1056/NEJMoa1716771.耐甲氧西林金黄色葡萄球菌（Methicillin-Resistant Staphylococcus Aureus, MRSA）存在-缺失数据集 本数据集的MRSA分离株采集自CLEAR（根除抗生素耐药性以改善生活，Changing Lives by Eradicating Antibiotic Resistance）试验。该试验旨在对比「重复去定植方案联合针对个人卫生与环境清洁的健康宣教」与「仅开展健康宣教」两种干预策略，对MRSA感染发生率与住院情况的影响。试验的研究对象招募自住院患者，入选标准为MRSA培养阳性或经监测拭子检测呈阳性。受试者入组后，分别于出院前后（ENRL）、首次随访后的1、3、6、9个月（依次记为V1至V4），采集受试者鼻前庭、皮肤、咽喉与伤口等不同身体部位的拭子样本；采集完成后，将拭子接种于显色琼脂培养基进行培养。由于去定植方案的实施周期仅为6个月，因此本研究仅对V3及之前的随访节点进行建模分析。需特别说明的是，部分入组受试者虽在住院期间的临床培养或监测拭子检测呈阳性，但在首个随访时间点（ENRL）的出院拭子样本中未检出MRSA。本研究纳入的受试者均为18岁以上成年人，其中卫生宣教组与去定植组的平均年龄为56岁（标准差Standard Deviation, SD=17）；两组的入选标准还包括：入组前30天内曾住院，且在入组住院期间或入院前后30天内的MRSA检测结果呈阳性。排除标准为接受临终关怀、或对去定植产品存在过敏反应。试验全程中，卫生宣教组1063名参与者共有98例（9.2%）发生MRSA感染，去定植组1058名参与者共有67例（6.3%）发生MRSA感染；其中84.8%的MRSA感染病例需接受住院治疗。有关受试者招募与入选标准、随访流程、样本采集及数据预处理的更多细节，可参阅参考文献https://www.nejm.org/doi/10.1056/NEJMoa1716771。