Non-synonymous mutations identified in WHV sequence of the inoculum prepared from the liver WHV-negative phase of POI and in the spleen from 8/M donor and in serum, PBMC and liver of E/F recipient injected with this inoculum.

For each of the WHV genome fragments sequenced, its length (bp) and location (nt) were enumerated according to the WHV/tm3 sequence (GenBank accession number AY334075). The amino acid change and location of each of the non-synonymous mutations identified were based on the predicated amino acid sequence of WHV/tm3. Only variants detected in 2 or more of 10 clones are reported. The number of amino acid changes found in a given WHV genomic region is presented as percentage of the total number of residues in the sequence analyzed. Non-synonymous mutations identified in WHV sequence of the inoculum prepared from the liver WHV-negative phase of POI and in the spleen from 8/M donor and in serum, PBMC and liver of E/F recipient injected with this inoculum.