Crystal structure of SADS-CoV main protease (Lys35Val) in complex with 27h

Crystal structure of SADS-CoV main protease (Lys35Val) in complex with 27h Descriptor: (2~{R})-1-[4,4-bis(fluoranyl)cyclohexyl]carbonyl-4,4-bis(fluoranyl)-~{N}-[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(pyridin-2-ylmethylamino)butan-2-yl]pyrrolidine-2-carboxamide, ORF1ab polyprotein Authors: Zeng, R, Lei, J. Deposit date: 2025-07-14 Release date: 2026-02-18 Last modified: 2026-03-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases. Plos Pathog., 22, 2026