Association of PRS with hospitalization status accounting for covariates and PC effects.

PRS was constructed using the three variants that passed the genome-wide significant P < 5E-8 threshold. The PRS association is significant (P = 5.25E-13) after controlling for genetic PCs and covariates (where sex is coded as males = 1 and females = 2, and age is standardized as (age-50)/10). Proportion of variance explained by PRS is 1.01% (calculated as 1-(1-R2full)/(1-R2null), where R2full and R2null represent R2 of models with and without the PRS, respectively).