Expression data from Adam10 knock out mice and wild type

Adam10, a cell surface protease, cleaving many proteins including TNF-alpha and E-cadherin. Here we investigate the genome wide effects of Adam10 knock out on the transcriptome. Commercial microarrays (Affymetrix Mouse Gene ST 1.0) were used to generate genome wide mRNA profiles. Mouse tissue samples from n=4 wiltype skin and n=4 Adam10 knockout skin were used in the study.Adam10作为一种细胞表面蛋白酶，可切割包括肿瘤坏死因子α（TNF-α）、E-钙粘蛋白（E-cadherin）在内的多种蛋白质。本研究探究了Adam10基因敲除对全基因组转录组的影响。实验采用商用基因芯片（microarray，Affymetrix Mouse Gene ST 1.0）构建全基因组mRNA表达谱，所用样本为4例野生型小鼠皮肤组织与4例Adam10基因敲除小鼠皮肤组织。