the peptide PDTLN1 induces the expression of a set of genes in P19 cells

In the present study, we disclose a new polypeptide corresponding to the sequence of human Talin-1 protein (named PDTLN1), which is highly expressed both in myocardial tissue and maternal peripheral blood of aborted fetuses with congenital heart disease (CHD). The results shown that PDTLN1, but not the scrambled version, caused cardiac developmental defects in zebrafish and inhibited cellular viability, proliferation and promoted apoptosis of P19 cells via the inhibition of PI3K/AKT signaling pathway. Our search may be helpful in gaining fresh perspective on the functions of human derived peptides and promote the detection of a novel class of diagnostic biomarkers in CHD. Further, to seek-and-find new targets for therapeutic intervention in CHD. Overall design: Identification of differentially expressed mRNAs after PDTLN1 treatment in P19 cells