Table_1_Effects of repetitive transcranial magnetic stimulation at different targets on brain function in stroke patients: a randomized controlled trial.DOCX

IntroductionRepetitive transcranial magnetic stimulation (rTMS) can improve post stroke motor function. However, there is little research on targets. The purpose of this study is to investigate the effects of rTMS therapy with different targets on post stroke motor function and neural plasticity.MethodsFifty-four subjects were randomly divided into M1 (Primary motor area) group, SMA (supplementary motor area) group and Sham group, and were given 10 Hz on the affected M1 area, SMA area and sham stimulation rTMS. The primary outcomes included Fugl-Meyer Assessment Upper Extremity Scale (FMA-UE), Fugl-Meyer Assessment Lower Extremity Scale (FMA-LE) and Berg balance scale (BBS). Secondary outcomes: amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo) and functional connectivity (FC) were analyzed by functional magnetic resonance imaging (fMRI) to evaluate brain functional activation and functional connectivity changes.ResultsThe 2-way repeated-measures ANOVA revealed a significant group × time interaction (F = 23.494, p

引言：经颅磁刺激（rTMS）可改善卒中后运动功能。然而，针对靶点的研究却相对匮乏。本研究旨在探究不同靶点rTMS治疗对卒中后运动功能和神经可塑性的影响。
方法：将54名受试者随机分为M1（初级运动区）组、SMA（辅助运动区）组和假刺激组，分别对受影响的M1区、SMA区和假刺激点进行10赫兹的rTMS治疗。主要结局指标包括Fugl-Meyer评估上肢量表（FMA-UE）、Fugl-Meyer评估下肢量表（FMA-LE）和伯格平衡量表（BBS）。次要结局指标：低频振荡幅度（ALFF）、区域一致性（ReHo）和功能连接（FC）通过功能性磁共振成像（fMRI）分析，以评估脑功能激活和功能连接的改变。
结果：双向重复测量方差分析显示，组别×时间交互作用具有统计学意义（F=23.494，p