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Comprehensive the effect of ZNRF1 on TLR3 activation in bone marrow-derived macrophages upon poly(I:C) stimulation

NIAID Data Ecosystem2026-03-14 收录

TLR3信号通路调控

ZNRF1功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA937412 数据链接链接失效反馈

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资源简介：

Znrf1+/+ or Znrf1-/- BMDMs were stimulated with poly(I:C) for 4 hours

应用场景：

创建时间：

2023-02-22

巨噬细胞免疫

TLR3信号通路调控

To evaluate the potential role of Hes1 in regulation of type I IFNs and the downstream ISGs expression, we generated the bone marrow-derived macrophages (BMDMs) from Hes1+/+ Cre-ERT2 and Hes1fl/fl Cre

NIAID Data Ecosystem60

Mus musculus strain:C57BL/6 Raw sequence reads. Mus musculus strain:C57BL/6

TLR3信号通路调控

基因敲除转录组

To evaluate comprehensively the effect of ZNRF1 on TLR3 activation, we performed RNA sequencing analysis of control and Znrf1-/- BMDMs challenged with poly(I:C).

NIAID Data Ecosystem40

TRIM38 Negatively Regulates TLR3-Mediated IFN-β Signaling by Targeting TRIF for Degradation

TLR3信号通路调控

蛋白质泛素化

Toll-like receptors (TLRs) mediated immune response is crucial for combating pathogens and must be tightly controlled. Tripartite motif (TRIM) proteins are a family of proteins that is involved in a v

NIAID Data Ecosystem10

Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway

病毒免疫逃逸机制

TLR3信号通路调控

Toll-like receptor 3 (TLR3) senses dsRNA intermediates produced during RNA virus replication to activate innate immune signaling pathways through adaptor protein TRIF. Many viruses have evolved strate

NIAID Data Ecosystem50

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

细胞代谢重编程

TLR3信号通路调控

Type I interferons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adaptive immune responses. On dendritic cells (DCs), IFNs facilitate their activation and

Figshare2016-01-18 更新10

Comprehensive the effect of ZNRF1 on TLR3 activation in bone marrow-derived macrophages upon poly(I:C) stimulation

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