Supplementary Material for: Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Neonates With Early-Onset Infection

Background: The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown.
Objectives: Determine the utility of nSOFA for EOS mortality.
Methods: Multicenter, retrospective cohort study of NICU patients with EOS between 2012-2023. nSOFA scores of survivors and non-survivors were compared and area under receiver operating characteristics curve (AUROC) for mortality was calculated.
Results: 104 subjects were identified (88 lived, 16 died). AUROC at blood culture collection (T0), 6 hours after collection(T6), and the maximum nSOFA at T0 or T6 (T0-6max) were 0.76 (95% CI 0.62, 0.91), 0.89 (0.80, 0.99), and 0.87 (0.77, 0.97), respectively. Analyses restricted to birthweight (<1.5, <1kg) or gestational age (<32, <29 week) cutoffs revealed AUROC ranges of 0.86-0.92 for T6 and 0.82-0.84 for T0-6max.
Conclusions: The nSOFA showed good-to-excellent discrimination of mortality among infants with EOS in the NICU.