Annual cost of the drugs for neovascular age-related macular degeneration (2008 reference price, Brazil) (US$ million).

1 real = US$2.00.a 4 mL of bevacizumab would provide 31 doses, including losses.b Usually this options are accompanied by Intravitreal anti-VEGF injections.c The Adjustment factor refer to the weighted average of real prices paid by the health care on every purchase in the same period. This was important to set a value closer of reality.d The cost of a 4 mL vial was divided into 40 doses, then 23% was subtracted from the volume of these doses to account for losses in the aliquoting process [13]. The aliquoting process was factored in at US$25.00.Annual cost of the drugs for neovascular age-related macular degeneration (2008 reference price, Brazil) (US$ million).