Pauletti et al._bioresponsive hydrogel_data tables

The overall objective of this project is to develop bioresponsive multifunctional hydrogel formulations suitable for establishing a highly viscous physical barrier at the cervicovaginal junction and, simultaneously, maintaining an acidic vaginal environment in the presence of alkaline semen to fortify the natural contraceptive barriers without the need for inclusion of a pharmacologically active drug molecule. To accomplish the desired contraceptive endpoint, this study describes selection of pharmaceutically acceptable formulation excipients, assessment of bioresponsive viscoelastic properties, and gel phase pH values under simulated physiological conditions in vitro, estimation of cervicovaginal safety and contraceptive efficacy in vitro, as well as safety and contraceptive efficacy in vivo using the rabbit model.