Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589
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Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589 Descriptor: 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1H-imidazole-2-carboxamide, Tyrosine-protein kinase ABL1 Authors: Zhou, T, Commodore, L, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. Deposit date: 2010-09-22 Release date: 2010-12-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance. Chem.Biol.Drug Des., 77, 2011
创建时间：
2010-09-22
