Activated NTRK3 stimulates PI3K activity

Activation of PI3K signaling downstream of NTRK3 (TRKC) is evident from PI3K-dependent activating phosphorylation of AKT in response to NTRK3 activity. SRC and IRS1 contribute to NTRK3-mediated induction of PI3K activity, but the exact mechanism is not known (Tognon et al. 2001, Jin et al. 2008).

NTRK3（TRKC）下游PI3K信号通路的激活可从NTRK3活性引发的AKT的PI3K依赖性激活磷酸化中得到证实。SRC和IRS1参与NTRK3介导的PI3K活性诱导，但其确切机制尚不明确（Tognon等人，2001年；Jin等人，2008年）。