Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660

Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660 Descriptor: Bromodomain-containing protein 4, N,N'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} Authors: Ren, C, Zhou, M.M. Deposit date: 2018-06-06 Release date: 2018-07-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.958 Å) Cite: Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115, 2018