AKT1 E17K mutant phosphorylates TSC2, inhibiting it
收藏reactome.org2025-03-22 收录
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AKT1 E17K gain-of-function mutant is expected to phosphorylate TSC2 and inhibit it, like the wild-type AKT (Inoki et al. 2002, Manning et al. 2002), but this has not been experimentally tested.
AKT1 E17K功能获得突变体预期将磷酸化TSC2并抑制其活性,类似于野生型AKT(Inoki等,2002年,Manning等,2002年),然而,这一效应尚未经过实验验证。
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