Fold changes in bioclinical parameters according to the 3 groups during low calorie diet and during weight maintenance diet.

Fold changes were calculated as ratio between the end of LCD and baseline (LCD phase), and the end of WMD and the end of LCD (WMD phase). Wilcoxon test stands for comparison between each time point:a, significant between baseline and the end of LCD or between the beginning and the end of WMD. Kruskal-Wallis rank sum test stands for variance among 3 groups during each phase:b, significant difference among 3 groups. Significance is set at 0.05. Mann and Whitney test stands for comparison between 2 groups during each phase (LCD, low calorie diet or WMD, weight maintenance diet):c, significant difference between A and B;d, significant difference between A and C;e, significant difference between B and C. Significance is set at 0.01, after adjustment for multiple comparisons.HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; LCD, low calorie diet; SBP, systolic blood pressure; DBP, diastolic blood pressure; CRP, C reactive protein; WMD, weight maintenance diet. Values are means ± SD.