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A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

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NIAID Data Ecosystem2026-05-01 收录
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Thermal Proteome Profiling (TPP) allows for identification of drug (off-)targets by evaluating shifts in apparent melting temperature for proteins. In this study, we use TPP to identify the targets for a novel antifolate (C1).

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2023-08-08
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