Transcriptome of natural aging mice livers

Aging is a complex biological process accompanied with time-dependent functional decline that affects most living organisms. Several interventions, including rapamycin, senolytics, NAD precursors, sirtuin-activating compounds, metformin, exercise and calorie restriction, are found to potentially increase healthspan and/or lifespan. However, pivotal methods to intervene aging are still in deficiency, because global view of natural aging is far from completeness by now. Omics analysis has the advantage to deliver an overall profile for biological processes. Liver is the biggest metabolic organ in mammals, but its global alterations during natural aging is unclear. Hereby, we performed transcriptome analysis with the liver of differentially aged mice under physiological conditions to obtain a fundamental dataset for future aging research.