Transcriptome analysis of renal cortex from mice subjected to cecal ligation and puncture compared to control mice [RNA-seq]

Sepsis is a complex syndrome characterized by organ dysfunction triggered by dysregulated host response to infection, and the kidney is the most commonly injured organ. To model septic-induced AKI in animal, a well-established mouse model induced by caecal ligation and puncture (CLP) was established. Overall design: To reveal the dysregulated mRNAs in renal cortex from Sham and CLP mice, we carried out global gene expression profiling by using RNA sequencing technology. We collected the renal cortex fom mice subjected to CLP treatment (n=3) and control mice (n=3). Comparative gene expression profiling analysis of RNA-seq data for CLP mice and control mice.