Axin2, GSK3B data

Pathogenic bacteria located in the vagina and cervix have the potential to migrate to the endometrium and induce a proinflammatory cytotoxic response in the endometrial cavity, potentially damaging the embryo or preventing its implantaPathogenic bacteria located in the vagina and cervix have the potential to migrate to the endometrium and induce a proinflammatory cytotoxic response in the endometrial cavity, potentially damaging the embryo or preventing its implantation. The predominant Lactobacillus species act to suppress the growth of other pathogenic bacteria in the vaginal environment. Alterations in Wnt signaling-related genes, such as GSK3β and Axin2, have been significantly implicated in recurrent miscarriage.
Given the importance of understanding the complex mechanisms governing uterine tissue function and factors affecting embryo implantation, along with evidence that demonstrates the role of the vaginal bacterial flora in the continuation of pregnancy, in this study we investigated the changes in the expression of the above two genes in an endometrial cell line (ENSC) with the aim of investigating the effect of Lactobacillus crispatus extract on them.
Our research showed that the bacteria has positive influence on the expression of some of Wnt1 pathway genes. Axin2 gene had significantly higher expression than that of GSK3β. No significant alterations in gene expression were detected in the untreated ENSC cell lines.
tion. The predominant Lactobacillus species act to suppress the growth of other pathogenic bacteria in the vaginal environment. Alterations in Wnt signaling-related genes, such as GSK3β and Axin2, have been significantly implicated in recurrent miscarriage.
Given the importance of understanding the complex mechanisms governing uterine tissue function and factors affecting embryo implantation, along with evidence that demonstrates the role of the vaginal bacterial flora in the continuation of pregnancy, in this study we investigated the changes in the expression of the above two genes in an endometrial cell line (ENSC) with the aim of investigating the effect of Lactobacillus crispatus extract on them.
Our research showed that the bacteria has positive influence on the expression of some of Wnt1 pathway genes. Axin2 gene had significantly higher expression than that of GSK3β. No significant alterations in gene expression were detected in the untreated ENSC cell lines.