Sfrp1 knockdown in primary calvarial osteoblasts preferentially alters the expression of module 9 genes.

aME Chr.8 SNP r = correlation between module eigengene and the chr. 8 SNP (rs33030926) associated with module 9 and Sfrp1 expression.bHMDP Diff = mean % difference in module gene expression stratified by rs33030926 genotype ((genotype ‘TT’-genotype ‘CC’)/genotype ‘TT’ *100).cSiRNA Diff = mean % difference in module gene expression in as a function of Sfrp1 siRNA knockdown ((Sfrp1 siRNA-Scrambled Control)/Sfrp1 siRNA*100).dHMDP SiRNA = Pearson correlation between HMDP Diff and SiRNA Diff within each module.All P-values in bold are significant at P≤0.002 (Bonferroni corrected for the number of modules tested).