The Chd4 helicase regulates chromatin accessibility and gene expression critical for β-cell function in vivo [ATAC-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE217444
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To establish the role of Chd4 on controlling gene expression programs in the beta cell, we generated a tamoxifen-inducible, beta-cell-specific knockout mouse model; control (MIP-CreERT; Chd4flox/+;R26RtdTomato) and Chd4Db (MIP-CreERT; Chd4flox/flox;R26RtdTomato. Dispersed islets from tamoxifen treated control and Chd4Db mice were flow-sorted, and ATAC-Seq performed.
创建时间：
2023-06-01
