Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor NR05-03
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Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor NR05-03 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-1-(3,5-difluorophenyl)-4-{(2-ethylbutyl)[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl]amino}-3-hydroxybutan-2-yl]carbamate, Protease Authors: Kaur, J, Shaqra, A.M, Schiffer, C.A. Deposit date: 2025-08-14 Release date: 2025-12-24 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. Eur.J.Med.Chem., 304, 2025
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2025-08-14
