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G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells. G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells

NIAID Data Ecosystem2026-03-14 收录

合成致死性

雪旺细胞

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA907229 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2022-12-01

CRISPRi

合成致死性

Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CR

DataCite Commons2025-07-03 更新110

Aurora A kinase Inhibition Reprograms Metabolism dependent on PGC1α to Drive Synthetic Lethality with Fatty Acid Oxidation Inhibition in Glioblastoma [ATAC-Seq]

胶质母细胞瘤代谢重编程

合成致死性

By integration of transcriptome, CHIP-seq, ATAC-seq, proteomic and metabolite screening followed by carbon tracing (U-13C-Glucose, U-13C-Glutamine and U-13C-Palmitic acid) and extracellular flux analy

NIAID Data Ecosystem60

Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma

淋巴瘤靶向治疗

合成致死性

Knowledge of essential oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells bearing an oncogenic mutation while sparing normal cells. Lenalidomi

NIAID Data Ecosystem50

Stable overexpression and knockdown of mutant- or wild type SPOP in VCaP prostate cancer cells. Stable overexpression and knockdown of mutant- or wild type SPOP in VCaP prostate cancer cells

前列腺癌基因互作

合成致死性

Purpose: Little is known about the interplay of driver mutations that never co-occur within the same cancer cells. The latter scenario has been identified in prostate cancer where recurrent gene fusio

NIAID Data Ecosystem100

Gene expression of SLNs (Synthetic Lethal with Nutlin-3) on HCT116 cells

合成致死性

癌症药物响应

A subset of our SLNs would be upregulated by Nutlin-3 and down-regulated by 5-FU and that this differential regulation could potentially explain how cell fate choice is determined SLNs as a group were

NIAID Data Ecosystem60

G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells. G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells

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