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Glucocorticoid Receptor: MegaTrans Switching Mediates Repression of ERα-Regulated Transcriptional Program [ChIP-Seq]

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE81510
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资源简介:
The mechanisms underlying GR-dependent inhibition of ERα-regulated gene activation programs at the global genomic level have been poorly understood. We found the binding of GR in trans on ERα-activated enhancers results in gene and enhancer repression by disassembling the MegaTrans Complex. All ChIP-Seq experiments were designed to elucidate the mechanism involving GR-mediated repression of ERα-Regulated Transcriptional Program
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2019-05-15
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