Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C
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Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C Descriptor: 1-{4-[2-{[(2R)-1-(dimethylamino)propan-2-yl]oxy}-7-(3-hydroxynaphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Vigers, G.P. Deposit date: 2018-11-13 Release date: 2018-12-12 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med Chem Lett, 9, 2018
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2018-11-13
